In order to investigate the antiepileptic effects of clalcium antagonist, nimodipine, we studied the changes of seizure pattern and electroencephalographic finding of the epileptic rats befroe and after nimodipine administration which were
induced
by
stereotaxic instillation of penicillin solution into the right amygadala.
40 Sprague-Dowley rats were divided into 2 groups : the control group (n=10) which underwent craniectomy on the biparetal area and was instilled penicillin solution into the right amygdala on the basis of stereotaxic coordinates, and the
experimental
group (n=30) which was subdivided into 3 subgraups : nimodipine pre treatment group (n=10), nimodipine 0 minute post-treatment group (n=10) and nimodipine 20 minutes post-treatment group (n=10) depending on the intraperitoneal administration time
of
nimodipine.
@ES The results were as follows:
@EN 1) In control group typical epileptiform discharges were noted at 3.4±1.9 min after penicillin instillation and the frequency and amplitude of discharges were 9.8±2.2/sec, 25.0±3.9mm/50μV. The degree of behavioral siezure was between
stage
IV
and VI.
2) In nimodipine pre treatment group, there was inhibitory efiects of seizure development. The frequency and amplitude were significantly decreased and the degree of behavioral seizaure was attenuated in comparison to that of control group.
3) There was no statistical difference in effects of penicillin induced seizure between nimodipine 0 minute, 20 minutes post-treatment and control group.
This experiment provided that calcium antagonist showed inhibitory effects on the penicillin-induced epileptic rats, but did not prevent seizure propagation. And calcium currents might play a role to evoke seizue. Therefore calcium antagonist "
nimodipine " might be beneficial to the treatment of patients with seizure.
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